Potential Applications of Hydroxyapatite-Mineralized-Collagen Composites as Bone Structure Regeneration: a Review

Authors

  • Kushendarsyah Saptaji Department of Mechanical Engineering, Faculty of Engineering and Technology, Sampoerna University, Jakarta, Indonesia http://orcid.org/0000-0002-8821-5211
  • Dindamilenia Choirunnisa Hardiyasanti 1. Department of Mechanical Engineering, Faculty of Engineering and Technology, Sampoerna University, Jakarta, Indonesia 2. Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, 85721, USA
  • Muchammad Fachrizal Ali 1. Department of Mechanical Engineering, Faculty of Engineering and Technology, Sampoerna University, Jakarta, Indonesia 2. Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, 85721, USA
  • Raffy Frandito 1. Department of Mechanical Engineering, Faculty of Engineering and Technology, Sampoerna University, Jakarta, Indonesia 2. Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, 85721, USA
  • Tiara Kusuma Dewi 1. Department of Mechanical Engineering, Faculty of Engineering and Technology, Sampoerna University, Jakarta, Indonesia 2. Department of Aerospace and Mechanical Engineering, The University of Arizona, Tucson, AZ, 85721, USA

DOI:

https://doi.org/10.31328/jsae.v5i1.3577

Keywords:

Hydroxyapatite-Mineralized-Collagen, Tissue Engineering, Biomedical, Biocompatible Composites, Bone Scaffolds, Powder Metallurgy

Abstract

The composites materials are known for their flexibility due to the combinations of two or three different materials and manipulation of their compositions. The advantage offered by composite materials make it suitable for biomedical applications especially to be used for implants. There are three types of composites biocompatible materials namely Metal Matrix Composite (MMC), Ceramic Matrix Composite (CMC) and Polymer Matrix Composite (PMC). In order to produce the biocompatible composite materials, various manufacturing processes can be performed. The manufacturing processes of MMCs are stir casting and powder metallurgy; the typical manufacturing process for CMCs is powder metallurgy; and 3-D printing by synthesizing and cross-linking the networks is used for fabricating PMCs. One of the promising biocompatible composites is Hydroxyapatite Mineralized Collagen (HMC). The HMC is used to create bone scaffold in bone regeneration process. The suggested manufacturing process for HMC is hybrid process which collaborate Additive Manufacturing and CNC Machining. In this paper, the HMC is reviewed especially related with its properties, fabrication method, and existed experimentation. In addition, the three types of biocompatible composites are also discussed on the applications and its manufacturing processes.

References

D. Kiradzhiyska and R. Mantcheva, "Overview of Biocompatible Materials and Their Use in Medicine", Folia Medica, vol. 61, no. 1, pp. 34-40, 2019. Available: 10.2478/folmed-2018-0038.

W. Callister and D. Rethwisch, Materials Science and Engineering: An Introduction, 10th ed. Australia and New Zealand: WILEY, 2018.

F. Campbell, Structural composite materials. Materials Park, Ohio: ASM International, 2010.

"Particle Reinforced Composites | School of Materials Science and Engineering", Materials.unsw.edu.au, 2022. [Online]. Available: https://www.materials.unsw.edu.au/study-us/high-school-students-and-teachers/online-tutorials/composites/composite-types/particle-reinforced-composites. [Accessed: 1- Mar- 2022].

"Fibre Reinforced Composites | School of Materials Science and Engineering", Materials.unsw.edu.au, 2022. [Online]. Available: http://www.materials.unsw.edu.au/tutorials/online-tutorials/2-fibre-reinforced-compposites. [Accessed: 01- Mar- 2022].

Z. Terzopoulou, D. Baciu, E. Gounari, T. Steriotis, G. Charalambopoulou and D. Bikiaris, "Biocompatible Nanobioglass Reinforced Poly(ε-Caprolactone) Composites Synthesized via In Situ Ring Opening Polymerization", Polymers, vol. 10, no. 4, p. 381, 2018. Available: 10.3390/polym10040381.

L. Yu et al., "Intrafibrillar Mineralized Collagen–Hydroxyapatite-Based Scaffolds for Bone Regeneration", ACS Applied Materials & Interfaces, vol. 12, no. 16, pp. 18235-18249, 2020. Available: 10.1021/acsami.0c00275.

S. Srinivasan, R. Jayasree, K. Chennazhi, S. Nair and R. Jayakumar, "Biocompatible alginate/nano bioactive glass ceramic composite scaffolds for periodontal tissue regeneration", Carbohydrate Polymers, vol. 87, no. 1, pp. 274-283, 2012. Available: 10.1016/j.carbpol.2011.07.058.

X. Han et al., "Carbon Fiber Reinforced PEEK Composites Based on 3D-Printing Technology for Orthopedic and Dental Applications", Journal of Clinical Medicine, vol. 8, no. 2, p. 240, 2019. Available: 10.3390/jcm8020240.

S. Dutta, S. Gupta and M. Roy, "Recent Developments in Magnesium Metal–Matrix Composites for Biomedical Applications: A Review", ACS Biomaterials Science & Engineering, vol. 6, no. 9, pp. 4748-4773, 2020. Available: 10.1021/acsbiomaterials.0c00678.

C. H. Gireesh, K. D. Prasad, K. Ramji and P. Vinay, "Mechanical Characterization of Aluminium Metal Matrix Composite Reinforced with Aloe vera powder", Materials Today: Proceedings, vol. 5, no. 2, pp. 3289-3297, 2018. Available: 10.1016/j.matpr.2017.11.571.

A. Ramanathan, P. Krishnan and R. Muraliraja, "A review on the production of metal matrix composites through stir casting – Furnace design, properties, challenges, and research opportunities", Journal of Manufacturing Processes, vol. 42, pp. 213-245, 2019. Available: 10.1016/j.jmapro.2019.04.017.

Y. Alshataif, S. Sivasankaran, F. Al-Mufadi, A. Alaboodi and H. Ammar, "Manufacturing Methods, Microstructural and Mechanical Properties Evolutions of High-Entropy Alloys: A Review", Metals and Materials International, vol. 26, no. 8, pp. 1099-1133, 2019. Available: 10.1007/s12540-019-00565-z.

A. Khaskhoussi, L. Calabrese, M. Currò, R. Ientile, J. Bouaziz and E. Proverbio, "Effect of the Compositions on the Biocompatibility of New Alumina–Zirconia–Titania Dental Ceramic Composites", Materials, vol. 13, no. 6, p. 1374, 2020. Available: 10.3390/ma13061374.

K. Dienel, B. van Bochove and J. Seppälä, "Additive Manufacturing of Bioactive Poly (trimethylene carbonate)/β-Tricalcium Phosphate Composites for Bone Regeneration", Biomacromolecules, vol. 21, no. 2, pp. 366-375, 2019. Available: 10.1021/acs.biomac.9b01272.

P. Bhattacharjee, D. Naskar, T. Maiti, D. Bhattacharya and S. Kundu, "Investigating the potential of combined growth factors delivery, from non-mulberry silk fibroin grafted poly(É›-caprolactone)/hydroxyapatite nanofibrous scaffold, in bone tissue engineering", Applied Materials Today, vol. 5, pp. 52-67, 2016. Available: 10.1016/j.apmt.2016.09.007.

S. Wang et al., "Mineralized Collagen-Based Composite Bone Materials for Cranial Bone Regeneration in Developing Sheep", ACS Biomaterials Science & Engineering, vol. 3, no. 6, pp. 1092-1099, 2017. Available: 10.1021/acsbiomaterials.7b00159.

A. Nair, A. Gautieri, S. Chang and M. Buehler, "Molecular mechanics of mineralized collagen fibrils in bone", Nature Communications, vol. 4, no. 1, 2013. Available: 10.1038/ncomms2720.

A. Nair, A. Gautieri and M. Buehler, "Role of Intrafibrillar Collagen Mineralization in Defining the Compressive Properties of Nascent Bone", Biomacromolecules, vol. 15, no. 7, pp. 2494-2500, 2014. Available: 10.1021/bm5003416.

Z. Li, T. Du, C. Ruan and X. Niu, "Bioinspired mineralized collagen scaffolds for bone tissue engineering", Bioactive Materials, vol. 6, no. 5, pp. 1491-1511, 2021. Available: 10.1016/j.bioactmat.2020.11.004.

D. Zhang, X. Wu, J. Chen and K. Lin, "The development of collagen based composite scaffolds for bone regeneration", Bioactive Materials, vol. 3, no. 1, pp. 129-138, 2018. Available: 10.1016/j.bioactmat.2017.08.004.

S. LIU, S. CHEN and W. HSU, "Mineralized Collagen/Bioceramic Composite and Manufacturing Method Thereof", US 2012/0207839 A1, 2012.

K. Saptaji, M. Gebremariam and M. Azhari, "Machining of biocompatible materials: a review", The International Journal of Advanced Manufacturing Technology, vol. 97, no. 5-8, pp. 2255-2292, 2018. Available: 10.1007/s00170-018-1973-2.

Downloads

Published

2022-03-16

Issue

Vol. 5 No. 1 (2022): JSAE

Section

Articles